General Information

  • ID:  hor004499
  • Uniprot ID:  O46688
  • Protein name:  Somatostatin-28
  • Gene name:  SST
  • Organism:  Ovis aries (Sheep)
  • Family:  Somatostatin family
  • Source:  animal
  • Expression:  Ovine Hypothalamic
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0048018 receptor ligand activity
  • GO BP:  GO:0030334 regulation of cell migration; GO:0038170 somatostatin signaling pathway; GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0098982 GABA-ergic synapse

Sequence Information

  • Sequence:  SANSNPAMAPRERKAGCKNFFWKTFTSC
  • Length:  28(89-116)
  • Propeptide:  MLSCRLQCALAALSIVLALGGVTGAPSDPRLRQFLQKSLAAAAGKQELAKYFLAELLSEPNQTENDALEPEDLSQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
  • Signal peptide:  MLSCRLQCALAALSIVLALGGVTG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  SSTR1, SSTR2
  • Target Unid:  W5Q7Z2, W5NPT8
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 2.8卤0.3 minute; /168 seconds ( PubMed ID: 6127205 )

Structure

  • Disulfide bond:  17-28
  • Structure ID:  AF-O46688-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004499_AF2.pdbhor004499_ESM.pdb

Physical Information

Mass: 363235 Formula: C137H209N41O39S3
Absent amino acids: DHILQVY Common amino acids: A
pI: 10.51 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 8
Hydrophobicity: -73.21 Boman Index: -6420
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 14.29
Instability Index: 3444.64 Extinction Coefficient cystines: 5625
Absorbance 280nm: 208.33

Literature

  • PubMed ID:  6109284##6127205
  • Title:  Primary Structure of Ovine Hypothalamic somatostatin-28 and somatostatin-25